Cutting Image Histology

Publications

Manuscripts

A CCR2/CCR5 Antagonist Attenuates an Increase in Angiotensin II-Induced CD11b+ Monocytes from Atherogenic ApoE−/− Mice. Major T, Olszewski B, Rosebury-Smith. Cardiovascular Drugs and Therapy. 2009. First Online.

A Nonpeptide, Piperidine Renin Inhibitor Provides Renal and Cardiac Protection in Double-Transgenic Mice Expressing Human Renin and Angiotensinogen Genes. Major T, Olszewski B, Rosebury W, Okerberg C, Carlson T, Ostroski R, Schroeder R, Kowala MC, and Leadley R. Cardiovascular Drugs and Therapy 2008; 22(6): 469-478.

Development of a Mouse Model of Induced Staphylococcus Aureus Infective Endocarditis.  Gibson GW, Kreuser SC, Riley JM, Rosebury-Smith WS, Courtney CL, Juneau PL, Hollemback JM, Zhu T, Huband, MD, Brammer DW, Brieland JK, and Sulavik MC. Comparative Medicine 2007;57:563-569.

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Modulation of Lipoprotein Metabolism by Inhibition of Spingomyelin Synthesis in ApoE Knockout Mice. Park T, Panek R, Bak Mueller, Rekhter MD, Bak Mueller S, Rosebury W, Robertson A, Hanselman J,  Kindt E, Homan R, Karanthanasis K. Atherosclerosis 2006;189:264-272.

Inhibition of Sphingomyelin Synthesis Reduces Atherogenesis in Apolipoprotein E–Knockout Mice.  Park T, Panek R, Bak Mueller, Sandra,  Hanselman J, Rosebury W,  Robertson A, Kindt E, Homan R, Karathanasis S, Rekhter M. Circulation 2004;110:3465-3471.

Increased Revascularization Efficacy After Repeat Administration of an Adenovirus Encoding VEGF121. Perrin L, June J, Rosebury W, Robertson A, Keiser Joan.  Gene Therapy 2004;11:512-521.

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Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression.  Wang H, Olszewski B, Rosebury W, Wang D, Robertson A, Keiser JA. Biochemical and Biophysical Research Communications 2004;315;363-368.

Delayed Angiogenesis in Aging Rats and Therapeutic Effect of Adenoviral Gene Transfer of VEFG.  Wang H, Keiser JA, Olszewski B, Rosebury W, Robertson A, Koveski I, Gordon D.  Int J Mol Med 2004;4:581-587.

Broad-Spectrum Matrix Metalloproteinase Inhibitor Marimastat-Induced Musculskeletal Side Effects in Rats. Renkiewicz R, Qiu L, Lesch C, Sun X, Devalaraja R, Cody T, Kaldjian E, Welgus H, Baragi V. Arthritis Rheum. 2003; 48(6), 1742 – 1749.

Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) is Induced Upon Monocyte Differentiation and Is Expressed in Human Atheroma.  Major TC, Liang L, Lu X, Rosebury W, Bocan, TMA.  Arterioscler, Thromb, and Vasc Biol 2002;22:1200-1207.

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Molecular Sieving and Mass Spectroscopy Reveal Enhanced Collagen Degradation in Rabbit Atheroma. Chen J, Kindt E, Hallak H, Peterson JT, Rosebury WS, Hubbel A, Bocan TM, Rekhter  M.D. Atherosclerosis 2001;159:289-295.

The Combined Effect of Inhibiting both ACAT and HMG-CoA-Reductase May Directly Induce Atherosclerotic Lesion Regression.  Bocan TMA, Krause B, Rosebury WS, Lu X, Dagle C, Bak Mueller S, Auerbach B, Sliskovic R.  Atherosclerosis 2001;57:97-1058.          

The ACAT Inhibitor Avasimibe Reduces Macrophages and Matrix Metalloproteinase Expression in Athersclerotic Lesions of Hypercholesterolemic Rabbits.  Bocan TMA, Krause BR, Rosebury WS, Bak-Mueller S, Lu X, Dagle C, Major T, Lathia C, Lee H. Arterioscler Thromb Vasc Bio. 2000;20:70-79.

Hypercholesterolemia Causes Mechanical Weakening of Rabbit Atheroma.  Rekhter MD, Hicks GW, Brammer DW, Hallak H, Kindt E, Chen J, Rosebury WS, Anderson MK, Kuipers PJ, Ryan MJ. Circulation Research 2000;86:101-108. 

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Antiatherosclerotic Potential of PD146176, a Specific 15-lipoxygenase Inhibitor, In Diet and Chronic Injury-Induced Rabbit Models of Atherosclerotic Lesion Progression and Regression. Bocan TMA, Rosebury WS, Bak Mueller S, Kuchera S, Welch K, Daugherty A, Cornicelli. JA.  Atherosclerosis 1998;136:203-221.

Inhibition of Interleukin-1 Induced Biosynthesis of Stromelysin by the Calcium Antagonist TMB-(8-N,N-Diethylamino)octyl-3,4,5-trimethoxybenzoate HCl).  Baragi V, Sweat AM, Thompson M, Hawkins KL, Toy KA, Rosebury WS. Connective Tissue Research 1995;31:153-160.

Morpholigical Features of Feline Ocular Sarcoma in 10 Cats.  Dubielzig RR, Hawkins KL, Rosebury WS, Toy KA, Mazur M, Jasper T.  Veterinary and Comparative Ophthalmology 1994;4:7-12.

Insulin-Secreting Pancreatic (Islet Cell) Carcinoma in a Cat.  Hawks D, Peterson ME, Hawkins KL, Rosebury WS.  Journal of Veterinary Internal Medicine 1992;6:193-196

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Abstracts, Poster, & Presentations

A Reliable Method of In Vivo Hemodynamic Assessment in Various Experimental Models of Hypertension. Olszewski B, Major T, Rosebury W. Radiotelemetry, Pfizer Ann Arbor, Michigan. 2006.

A Murine Model of Aortic Damage.  Kreuser S, Riley J, Gibson G, Brammer DW, Brieland J, Courtney C, Rosebury W. AALAS National Meeting. Tampa Bay 2004 P057.

Evaluation of a Chronic Deep Venous Thrombosis Rat Model With Enoxaparin. Schroeder R, Rosebury WS, Leadley R. American Society of Hematology Meeting 2002.

Involvement of Matrix Metalloproteinase in the Development of Accelerated Atherosclerosis in ApoE -/- Mice.  Chen J, Brammer D, Kreuser S, Riley J, Madore S, Rosebury W, Robertson A, Rekhter M.  Experimental biology 2002.

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Accelerated Arteriosclerosis In Mice With Different Genetic Background.  Rekhter M, Hubbel A, Rosebury W, Robertson A, Gillespie P, Kreuser S, Riley J, Brammer D, Auerbach B. International Vascular Biology Meeting, 2002.

Induction of Plaque-Associated Thrombosis in a Murine Model of Accelerated Atherosclerosis (A Pilot Study).  Olsen K, Rosebury W, Robertson A, Schroeder R, Riley JM, Kreuser SC, Brammer D, Rekhter M. Experimental Biology 2002  A173.

Macrophage Accumulation in a Mouse Model of Accelerated Atherosclerosis.  Bak Mueller, S, Chen J, Robertson AW, Rosebury WS, Kreuser SC, Riley JM, Brammer D, Rekhter M.  Keystone Symposia 2002.

Selective Estrogen Receptor Modulators (SERMs) Augment bFGF-Induced Angiogenesis in the Ovariectomized (OVX) Mouse.  Lu G, Rosebury W, Robertson A, Karathanasis S, Panek R.  Experimental Biology 2001. 

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Molecular Sieving and Mass Spectroscopy Reveal Enhanced Collagen Degradation in Rabbit Atheroma.  Chen J, Kindt E, Hallak H, Peterson JT, Rosebury WS, Hubbel A, Bocan TMA, Rekhter MD.  Gordon Research Conference 2001.

Orally Administered Quinapril Potentiates the Angiogenic Effects of Growth Factors in an Angiogenesis Impaired Disease Animal Model.  Panek R, Lu G, Rosebury W, Robertson A, Karathanasis S.  .  American Heart Association 2001. 

The Impaired Angiogenesis in SHR Rats Can Be Improved with VEGF Treatement.  Wang H, Keiser J, Olszewski B, Rosebury W, Robertson A, Brough D, Gordon D. First Conference on Arteriosclerosis, Thrombosis, and Vascular Biology.2000.

A Mouse Ear Model of Angiogenesis Induced by CI-1023, An Adenovirus Encoding the Human Vascular Endothelial Growth Factor-121 Gene.  Flynn MA, Haarer S, Vincent PW, Rosebury WS, Kovesdi I, Keiser J, Gordon D.  American Society of Gene Therapy Meeting 2000.

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PD166793, A Matrix Metalloproteinase Inhibitor Blunts The Progression of Atherosclerosis in Rabbits in the absence of  Plasma Cholesterol Lowering.  Bocan T, BakMueller S, Rosebury W, Hallak H, O’Brien P, Dable C, Robertson A, Lu X, Major T.  Presentation at XIIIth International Symposium of Atherosclerosis 2000. Stockholm, Sweden.

The ACAT Inhibitor, Avasimibe, Reduces Aortic Cholesterol Content in ApoE Knockout Mice, Independent of its Plasma Hypocholesterolemic Effects. Auerbach BJ, Dash D, Bousley D, Essenburg A, Davila-Delgado E, Bocan T, Rosebury W, BakMueller S, Homan R, Krause B. XIIIth International Symposium of Atherosclerosis 2000. Stockholm, Sweden.  MoP08: H1

Plaque Rupture Thrombosis and Paraplegia Are Triggered By Corticotropin Releasing Factor:  A Pilot Study in ApoE Deficient Mice. Rekhter MD, Labatsky S, Meltzer LT, Rosebury W, Gibson G, Bocan TMA, Ryan M.  . XIth International Vascular Biology Meeting 2000. B073 Journal of Vascular Research.

Laser Capture Microdissection of Paraffin-Embedded Specimens For mRNA Analysis. Chen J, Rosebury W, Robertson A, Bocan TMA, Rekhter M.  FASEB J Vol 14, No 4 2000. A459

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The Impaired Angiogenesis in SHR Rats Can Be Improved With VEGF Treatment.  Wang H, Keiser J, Olszewski B, Rosebury W, Robertson A, Gordon D.  NAVBO Meeting 2000

A Mouse Ear Model of Angiogenesis Induced by CI-1023 an Adenovirus Encoding the Human Vascular Endothelial Growth Factor-121 Gene.  Flynn M, Haarer S, Vincent PW, Rosebury WS, Kovesdi I, Keiser J, Gordon D.  American Society of Gene Therapy 2000.

Can 15-Lipoxygenase Inhibitors Alter The Progression of Atherosclerosis?  Bocan TMA, Cornicelli J, Trivedi B, Vora J, Bak-Mueller S, Roark W, Welch K, Sorenson R, Rosebury W, Dagle C, Robertson A. XIIth International Symposium on Atherosclerosis 2000

PD166793, A Matrix Metalloproteinase Inhibitor, Blunts The Progression of Atherosclerosis In The Absence of Plasma Cholesterol Lowering.  Bocan TMA, Bak-Mueller S, Rosebury W, Hallak H, O’Brien P, Dagle C, Robertson A, Lu X, Major T. XIIth International Symposium on Atherosclerosis 2000

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The Effect of MMP-Inhibitor Treatment on Heart Failure Progression and Collagen Accumulation In SHHF Rats. Peterson JT, Dillon L, Rosebury W, Robertson A, Li H.  Gordon Conference on Matrix Metalloproteinases 1999

Left Ventricular Dilation Does Not Predict LV Dysfunction In The Myocardial Infarct (MI) Rat Heart Failure Model.  Dillon L, Olsen KF, Li H, Rosebury W, Peterson JT.  Heart Failure Society Meeting, San Francisco CA 1999

The Effect of Chronic MMP-Inhibition and Quinapril Treatment on Collagen Expression and Accumulation in Heart Failure.  Peterson JT, Rosebury W, Li H.  Circulation. American Heart Association Meeting, 1999

 

Thrombotic Complications of Atherosclerosis Are Triggered By Corticotropin Releasing Factor:  A Pilot Study in ApoE Deficient Mice.  Rekhter M, Wiley JN, Meltzer LT, Rosebury WS, Robertson A, Bocan TMA, Ryan MJ.  Circulation. American Heart Association Meeting 1999

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The Delayed Angiogenesis Seen in Aged Rats Can Be Accelerated by Adenoviral Gene Transfer of VEGF.  Wang H, Olszewski B, Rosebury W, Robertson A, Gordon D, Keiser J.  Circulation.  American Heart Association Meeting, 1999

Even Hardened Arteries Have Their Soft Spots.  Rekhter M, Kindt E, Hallak H, Choi C, O’Donnell M, Rosebury W, Hicks G, Brammer D, Ryan M. FASEB J 13:A206, 1999

Hypercholesterolemia-Induced Weakening of Rabbit Atherosclerotic Plaques is Associated With Alterations In Collagen Turnover.  Rekhter M, Hicks G, Brammer D, Kuipers P, Rosebury W, Gordon D, Ryan M.. Circulation. American Heart Association Meeting 1998

Matrix Metalloproteinase Inhibitor, PD 166793, Alters Progression of Heart Failure In The Myocardial Infarcted Rat.  Peterson JT, Sanchez B, Robertson A, Rosebury W, Bryant JW,  Dillon L, Hallak H, Johnson L, Bocan TMA.  Circulation 1998; 98: 418. American Heart Association Meeting 1998

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Coadministration of the ACAT Inhibitor, CI-1011, and Simvastatin Induces Atherosclerotic Lesion Regression.  Bocan TMA, Rosebury WS, Lu X, Dagle C, Bak Mueller S.  Circulation 1998  98:I-310 American Heart Association Meeting 1998 Presentation.

HMG-CoA Reductase and ACAT Inhibitors Act Synergistically To Lower Plasma Cholesterol and Limit Atherosclerotic Lesion Formation In The Rabbit.  Bocan TMA, Rosebury WS, Bak Mueller S. Presentation In Paris, France 1997 

Might ACAT Inhibitors Promote Development of a Stable Plaque Morphology? American Heart Association Meeting.  Bocan TMA, Rosebury WS, Bak Mueller S, Milad M, Lathia C, Homan R.. Circulation 1997 96:I-491

Matrix metalloproteinase Inhibition Blocks Progression of Heart Failure.American Heart Association Meeting. Peterson JT, Rosebury WS, Robertson AW, Washington RA, Li H, Obrien PM, Sliskovic DR,Hallak H, Bocan TMA.  Circulation 1997 96:I-250

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CI-1011 Blocks Atherosclerosis Progression in Cholesterol-Fed Low Density Lipoprotein Receptor Deficient Mice.  Essenburg A, Doan TM, Rosebury W, Auerbach B, Barnett B, Bocan TMA, Bisgaier C.. American Heart Association Meeting. Circulation 1997 96  

Histological Crayons: Procedures For Combining Single, Double, and Triple Immunohistochemical Stains And The Verhoeff Elastin Stain In Rabbit Vasculature.  Rosebury WS, Bocan TMA.  1997 Drug Discovery Symposium, U of M.

A Procedure For Combination of Verhoeff Elastin Stain with Multiple Immunohistochemical Stains in Rabbit Vasculature.  Rosebury WS, Bocan TMA.  . Microcirculation 1997 4:189

PD 146176, A Novel, Potent, Specific Inhibitor of 15-Lipoxygenase Attenuates Atherosclerosis in Diet and Chronic Injury-Induced Models of Lesion Progression and Regression. Cornicelli J, Rosebury W, Lee P, Bak-Mueller S, Kuchera S, Welch K, Gaugherty A, Bocan TMA. Presentation Pavia, Italy 1996

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Stable Expression of Human 15-Lipoxygenase in a Murine Macrophage Cell Affects Cellular Function Welch K, Schultz P, Rosebury W, Cornicelli J. Poster- San Francisco, California 1996.

Early lipid accumulation and temporal changes in cell phenotype in ascending aorta of cholesterol-fed rabbits.  Babaev VR, Rosebury WS, Lee PJ, Bocan TMA  FASEB J  1995, 9: A319.

PD148817: A potent and bioavailable ACAT inhibitor with antiathersclerotic activity in cholesterol-fed rabbits. Sliskovic DR, Picard JA, Anderson MK, BakMueller S, Bocan TMA, Bousley R, Essenberg AD, Krause BR, Kuchera S, Lee P, Rosebury WS, Speyer CL, Stanfield RL, Turluck D 12th International Symposium on Drugs Affecting Lipid Metabolism Houston, Texas 1995, p 100

CI-1011, An ACAT Inhibitor With Paradoxical Antiatherosclerotic Activity.  Bocan TMA, Rosebury WS, BakMueller S, Lee P,  Kuchera S, Lee H.  12th International Symposium on Drugs Affecting Lipid Metabolism Houston, Texas 1995, p 132

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Antiatherosclerotic and Hypolipidemic Activity of Atorvastatin, an HMG-CoA Reductase Inhibitor, and CI-976, an ACAT Inhibitor, When Administered in Combination.  Bocan TMA, BakMueller S, Rosebury WS, Lee P, Quenby-Brown E, Mazur MJ, Krause BR.  12th International Symposium on Drugs Affecting Lipid Metabolism Houston, Texas, 1995 p 42